Highlights
โฆ until now.
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) November 29, 2023
I could not be more thrilled to have matched at @WeilCornell this year for heme/onc fellowship and fulfill a dream that has been over a decade in the making.
Excited to join @WCM_MeyerCancer being led by the amazing @wolchokj and @merghout
See you in July!!! https://t.co/YfQzbVGk29 pic.twitter.com/gmH8VHdvcW
During my PhD, I was a visiting scholar at @MSFTResearch
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) November 3, 2023
We extended the multiple-instance learning framework developed in #DeepTCR to somatic variants in cancer.
Excited to share Aggregation Tool for Genomic Concepts (#ATGC), now out in @natBME https://t.co/BCymfrXAp7
In one of my fellowship interviews this year, I was asked about the last time I found myself lost in an activity.
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) October 18, 2023
It instantly brought to mind the unique experience of immersing myself in the creative process of making music, which is unlike anything else I do - when Iโm in it,โฆ pic.twitter.com/QS86ffoCs1
One of my greatest fears upon entering residency was the potential toll it could take on the foundational habits of diet and exercise that I had diligently maintained for many years. I was aware that within a few years, if I didn't intentionally prioritize my physical health, itโฆ pic.twitter.com/qw991kIEQR
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) October 2, 2023
Excited to present my latest work using a multiple instance #deeplearning approach in single-cell spatial IHC data to predict clinical outcomes in #CheckMate275 (nivolumab in metastatic urothelial carcinoma after platinum therapy)! See you at #SITC in beautiful San Diego in aโฆ pic.twitter.com/OtTOPOjWPt
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) September 28, 2023
First open water 5k swim in the books (1:52), and I could not be more proud to have done it for such a personally meaningful cause (#SAA), being part of an effort that raised 1.8 million dollars today to continue supporting groundbreaking cancer research.
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) July 29, 2023
โข
8 weeks ago, when Iโฆ pic.twitter.com/eUipCHdOGE
Grateful to have been invited to participate in this #AI x #Bio Summit at the @NYSE today. Amazing to be having discussions about the future of AI in biology & medicine with such like-minded and visionary individuals. pic.twitter.com/Q1H99KHKzW
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) July 13, 2023
A cold rainy #NYC morning couldnโt keep our spirits down as co-resident @lodoe_sangmo and I had a blast finishing our first half marathon @BK_HalfMarathon @MSH_MedChiefs !!! pic.twitter.com/wdREnSs9dc
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) April 23, 2023
Tumor mutational burden (TMB) has become a promising predictor of response to immunotherapy.
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) February 27, 2023
We propose probabilistic mixture models to better predict true TMB from panel data, resulting in improved predicted survival in #TCGA data.@CRC_AACR @AACR https://t.co/3A8pJil6dy
The dream is not dead. It is merely postponed. pic.twitter.com/IGrKAz5vNh
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) November 30, 2022
In case you didnโt knowโฆ pic.twitter.com/zHzElE3jTj
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) November 23, 2022
5 years ago, I proposed using #DeepLearning to predict response to immunotherapy in TCR-Seq.
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) September 16, 2022
๐งฌ๐งฌ๐งฌ๐งฌ
Last year, we published #DeepTCR. Today, I am proud to share its application in cancer immunology, now out in @ScienceAdvances #ScienceResearch
๐ถ๐ท๐ถ๐ทhttps://t.co/VRxPqwZP5F
Getting to experience being a senior resident for a day and joining morning report on this beautiful April morning! @IcahnMountSinai @MountSinaiNYC @DOMSinaiNYC pic.twitter.com/18M9fT5P2U
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) April 14, 2022
Incoming interns, donโt subscribe to the idea that you must sacrifice your health during residency.
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) April 5, 2022
I swore to myself last July that I would not let clinical training rob my health.
32 y/o, 4 years s/p back surgery, almost at end of intern year, Iโm finding my strength again. pic.twitter.com/dU1SXX0dWJ
Even in the business of intern year, thrilled to have made it down to speak in the nationโs capital at #SITC2021 . As always, grateful to @sitcancer for giving me this platform to speak about my research on multiple occasions. pic.twitter.com/Dfk1UvEnna
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) November 12, 2021
Itโs not lost on me how special it is to be given this award on 3 separate occasions. Thanks @sitcancer for the continuous and repeated support of my research in the field of cancer immunology. #sitc2021 #sitc21 pic.twitter.com/OtjnYUWdic
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) November 12, 2021
So excited to be returning for the 3rd time to the @sitcancer Annual Meeting as a speaker and to receive a young investigator award for my work using #DeepTCR to predict response to checkpoint blockade! Cya in November!! pic.twitter.com/O9MqxOhO07
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) August 28, 2021
In follow-up to the #DeepTCR manuscript, I am excited to share work revealing both quantitative and qualitative features of TCR repertoire that are predictive of clinically severe #SARSCoV2 infection in the #ImmuneCODE db @AdaptiveBiotech @MSFTResearch https://t.co/64ksI4Qn9P
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) July 12, 2021
I met @DocEShenderov at the @bloombergkimmel retreat a few yrs ago and we immediately hit it off. After spending an hour chatting in the parking lot, he proposed a potential collaboration. Our manuscript is now available at @Nature_NPJ Precision Oncology! https://t.co/MGTHxn16in
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐, ๐๐ก๐ (@John_Will_I_Am) May 14, 2021
With graduation around the corner, I took time to reflect on my "formal" years of education.
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) April 5, 2021
This probably is the single most important lesson I learned over those 14 years.https://t.co/hh06IFRAXw
In 2017, I attended a talk by @Google at @AACR on #DeepLearning. I realized then the potential for deep learning for analyzing TCR-Seq data & thus, the idea for #DeepTCR was born. 4 years later, our manuscript is now available at @NatureComms https://t.co/Gx6ujCt9ux
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) March 11, 2021
Very excited to share our latest #TPG episode where we build on Part 1 of "Rounding w/ Dr. Bayes" and incorporate the use of #pymc3 probabilistic programming approach to walk through this clinical vignette. Be sure to follow our main twitter account to stay up to date! @pymc_devs https://t.co/VOhL2qVpxw
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) January 12, 2021
Our #ASH2020 abstract is now live! We present a multiple-instance deep learning model capable of rapidly identifying t(15;17) #APL from peripheral smear, potentially allowing more timely and appropriate therapy to this aggressive form of leukemia. https://t.co/rkeP6RHtyK pic.twitter.com/ikHzqUM5kv
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) November 4, 2020
Certified & Submitted โ
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) October 19, 2020
I canโt help but feel overwhelmed that the last 8 years has led me to this moment and honestly, terrified about the uncertainty that lies ahead. I also feel a profound sense of accomplishment and hope for the future. Que Sera, Sera.#ERAS#Match2021
Seeing everyone post about their accepted presentations for #ASH20 has us so excited! Congratulations, Dr. Sidhom.
— ASH (@ASH_hematology) October 15, 2020
The Physician’s Garage (TPG)
Excited to be involved with this brain child of Vineet Tiruvadi (@vineettiruvadi) who has seen this opportunity to synthesize the worlds of engineering and clinical medicine in quite a unique way by trying to formalize clinical reasoning through the use of statistical inference. I believe thinking about clinical reasoning through this lens will be transformative for many reasons but particularly with the creation of artificially intelligent systems in medicine. Below, Vineet, Bilal Bari (@bari_bilal), and I discuss the basics of inference within a clinical framework. See more episodes here.
Sub-Internship โ๏ธ
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) August 14, 2020
โข
Another significant step to MD โ๏ธ
โข#aequanimitas @OslerResidency @HopkinsMedicine @HopkinsMDPhD pic.twitter.com/EyRXorU0yC
Also for those interested in visualizing flow cytometry data, check out ExCYT. Here, we plot all cells across all markers and highlight populations with these box plots to visually appreciate which markers are differentially expressed between clusters. https://t.co/C2hpGfnB6m pic.twitter.com/16mDauTEh9
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) August 1, 2020
๐๐จ๐๐๐ฒ, ๐ ๐๐๐ ๐ข๐ง ๐ฆ๐ฒ ๐๐ข๐ซ๐ฌ๐ญ ๐๐ฅ๐ข๐ง๐ข๐๐๐ฅ ๐๐ฅ๐๐๐ญ๐ข๐ฏ๐ ๐ข๐ง ๐ฆ๐๐๐ข๐๐๐ฅ ๐จ๐ง๐๐จ๐ฅ๐จ๐ ๐ฒ; ๐๐ฅ๐ฆ๐จ๐ฌ๐ญ ๐ ๐ฒ๐๐๐ซ๐ฌ ๐๐๐ญ๐๐ซ ๐ ๐๐๐๐ข๐๐๐ ๐ญ๐จ ๐ฉ๐ฎ๐ซ๐ฌ๐ฎ๐ ๐ ๐๐๐ซ๐๐๐ซ ๐ข๐ง ๐จ๐ง๐๐จ๐ฅ๐จ๐ ๐ฒ. #MedEd pic.twitter.com/ccFBUGPEnl
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) June 15, 2020
I have to pinch myself to think an idea that we came up with in a small lab at Johns Hopkins is now actually being used to treat cancer. Enjoy some of these throwback photos of early prototypes showing how far the CryoPop has come since its infancy. #TheDreamRealized pic.twitter.com/VbHQnB5kmZ
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) June 1, 2020
this cannot be overstated. especially in singe-cell visualizations where we can be looking at extreme over plotting. Another approach I personally use is to do a kernel density estimation of the visualized data and use it as a color scheme (see attached visualization + code). https://t.co/iYipgRulLc pic.twitter.com/f94wCIifGt
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) May 15, 2020
MSTP colleagueโs doctoral work published today in @NatureSMB !! https://t.co/zQz0RBio1F
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) February 10, 2020
Latest DeepTCR pre-print is on BioRxiv! This expanded work now demonstrates the use of deep learning to predict response in a clinical trial to anti-PD1 therapy from pre-treatment biopsies! DeepTCR is still looking for the right journal to call home! https://t.co/0aOC6ddlLk
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) December 23, 2019
So proud of Eriene who successfully defended her PhD thesis yesterday @harvardmed @BrighamWomens @broadinstitute Congratulations Dr. Sidhom! #WomenInScience #doubledocs pic.twitter.com/RFSH9awWS3
— Anna Greka (@AnnaGreka) May 4, 2019
Do YOU do TCR-Seq? Looking for better ways to analyze your data? If so, look no further and be sure to stop by the Convergence Minisymposium on Tuesday at 3pm to hear about DeepTCR and how you can begin using it today!! #AACR2019 #AACR19 @AACR @dpardol1 pic.twitter.com/8FsUIFRkX7
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) March 31, 2019
Defending my dissertation today at 1 pm in CRB2 - 111. Excited to be presenting on โApplications of Artificial Intelligence and Machine Learning in Cancer Immunologyโ @JHUBME @JohnsHopkins @HopkinsMedicine @HopkinsEngineer @BloombergKimmel
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) December 7, 2018
Congrats soon to be Dr. @John_Will_I_Am So very proud of all of your accomplishments. Grateful to be a part of your journey!! https://t.co/8YnSCrBLeZ
— Aileen Huang-Saad (@aileenUM) December 6, 2018
To one of the first people ever to believe in me when I was a freshman in college. She made me believe I could accomplish anything. Now Iโm 1 day away from defending my dissertation as an MD/PhD candidate at @JohnsHopkins (@aileenUM is also a @JHUBME PhD graduate) https://t.co/yjCrmsGr4T
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) December 5, 2018
If you're at #SITC2018 and do TCRSeq, you will want to check out my talk @ 1pm in 204 on DeepTCR, a deep learning framework and easy-to-use python package to uncover structural concepts within TCR repertoire! https://t.co/Td8g6Ucmmu
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) November 9, 2018
Excited to release DeepTCR, a python package for uncovering structure in TCRSeq data using unsupervised and supervised deep learning methods! Will be speaking on it @ #SITC2018 this Friday!! @larmanlab @dpardol1 https://t.co/7a9qFpXD0L
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) November 7, 2018
John-William Sidhom, a biomedical engineering MD/PhD student at @JohnsHopkins, is among the group of researchers using AI technology to chart immune cell receptor. https://t.co/DuB2EekOKX
— Johns Hopkins BME (@JHUBME) January 8, 2018
#AI helps map โantennasโ on immune system cells. Researchers created โImmunoMapโ with #AI technology to help chart a kind of antenna on immune system cells.
— Hopkins Med News (@HopkinsMedNews) January 8, 2018
https://t.co/K8JZsPB9nM pic.twitter.com/HW7A6bnnuM
๐ pic.twitter.com/1TgLAtQVUt
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) August 30, 2016
Not much of a blogger/writer but had this awesome opportunity to write for @CMANAservice https://t.co/ioCJYZihlr pic.twitter.com/6OCtCxUt1x
— ๐๐จ๐ก๐ง-๐๐ข๐ฅ๐ฅ๐ข๐๐ฆ ๐๐ข๐๐ก๐จ๐ฆ, ๐๐๐ (@John_Will_I_Am) August 24, 2016
Our Q&A w @HopkinsMedicine John-William Sidhom https://t.co/Re5Jh24IUF Talk on immune repertoire analysis @ 4:20 PM Lev1/Rm151 #AACR2017
— Adaptive Biotech (@AdaptiveBiotech) April 2, 2017